The Trisomy 13 and 18 Collaborative is pleased to invite research teams to submit letters of intent (LOI) and, if invited, proposals to carry out research that will improve clinical care and experiences for families and children impacted by trisomy 13 or 18. The research approaches can range from data collection studies to dissemination and implementation projects, informed by family experiences and needs.
LEARN MORE: 2026 Trisomy Collaborative Request for Proposals (PDF)
The Collaborative will issue awards of up to $250,000 for one-year projects or $500,000 for two-year projects to research teams affiliated with a university, academic medical center, or non-profit organization based in the United States or Canada. These teams will serve as research partners to carry out a broad range of projects aimed at improving clinical care and family experiences. Through these awards, the Collaborative seeks to better understand and improve patient-clinician relationships, clinical care and outcomes, and navigation of the medical system for families impacted by trisomy 13 and 18. Research findings will inform future efforts to develop guidelines for clinical care, clinician training programs, and family resources.
To help applicants better understand the range of projects that may be supported, the Trisomy Collaborative has identified examples of topics and themes that could be important for improving clinical care and experiences for families impacted by trisomy 13 or 18. These concepts were generated during strategic sessions focused on needed research to improve care. Notably, applicants need not feel limited to these topics or themes in their proposals, as selection criteria are focused more broadly on the capacity of a project to advance clinical care and family experiences:
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Understanding common clinical problems, interventions, and clinical outcomes.
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Developing care pathways that meet the needs of families, from prenatal pathways to transitions to adult care, and everything in between.
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Understanding clinician experiences and/or addressing potential clinician disability bias.
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Facilitating clinician-patient communication, spanning from those involved in initial family communication such as obstetricians, genetic counselors, and neonatologists, to those with ongoing relationships, such as primary care, complex care, or palliative care clinicians.
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Development of stories/narratives that can improve clinical care or family experience, including stories of families or clinicians.
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Understanding regional differences in clinical service availability and/or the reproductive policy environment and their impact on care.
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Enhancing family navigation of healthcare and social environments.
WEBINAR FOR MORE INFORMATION:
The Trisomy 13 and 18 Collaborative will host an informational webinar on June 3, 2026 at 3:00 pm ET / 12:00 pm PT, on the Trisomy Roundtable platform. Interested applicants are encouraged to sign up to join the Roundtable.
If you cannot attend the webinar, signing up as a roundtable member will allow you to view a recorded version of the session.
